Zeng et al. (1997) proposed a seven layer optical model for solving steady-state autofluorescence of skin. The model includes the thickness and optical properties (κλ, σλ, c, and Φλ) of each layer of the skin for the excitation wavelength λex=442 nm and the autofluorescence wavelength of λem=520 nm. The above Figure compares our numerical results with those obtained by Zeng et al. (1997) using the Monte Carlo method to solve the above light transport Equations. Good agreement between the two methods (within 5% relative error) is observed. Note that the excitation light is completely attenuated at a depth of 0.6 mm within the skin. In addition, Zeng et al. (1997) compared their numerical results with in vivo measurements of steady-state autofluorescence of skin for Caucasian and Asian patients (Fig.7) thus, confirming the validity of the skin optical model and the simulation tool developed.

Zeng, H. , MacAulay, C. , McLean, D. I. , and Palcic, B. , 1997. Reconstruction of in vivo skin autofluorescence spectrum from microscopic properties by Monte Carlo simulation, Journal of Photochemistry and Photobiology B: Biology, Vol. 38, pp.234-240.