Optoelectronic Tweezers (OET)
Optoelectronic tweezers in general refers to light induced electrokinetic mechanisms for manipulation of various millimeter, micrometer, and nanometer objects including droplets, live cells, and molecules on optoelectronic devices. Our research in this direction focuses on developing low cost optoelectronic devices for high throughput manipulation of these objects in various environments (oil, air, aqueous media), their fundamental limitations, and applications. Representative works include optoelectronic tweezers (OET) enabling manipulation of live cells in microfluidics with light intensity 5 orders of magntiude lower than conventional optical manipulation using direct optical forces, and optoelectrowetting (OEW) enabling light triggered electrowetting to inject, transport, split, and merging picoliter to microliter droplets on top of a LCD monitor.
Selective Publication
-P. Y. Chiou, Aaron T. Ohta, Ming C. Wu,ˇ¨ Massively parallel manipulation of single cells and microparticles using optical images," Nature, vol. 436, pp. 370-372, 2005.
-Arash Jamshidi, Peter J. Pauzauskie, P. James Schuck, Aaron Ohta, P. Y. Chiou, J. Chou, Peidong Yang, and Ming C. Wu ,ˇ¨ Dynamic manipulation and separation of individual semiconducting and metallic nanowires,ˇ¨ Nature Photonics, vol. 2, pp. 86-89, 2008. (Cover Paper)
-Park, S., Teitell, M. A., Chiou, P. Y., ˇ§Light patterned continuous electrowetting on a single photoconductive surface,ˇ¨ Lab on a Chip, Vol 10, pp 1633-1740, 2010. (Selected as inside cover paper)
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Photothermal Nanoblade for Cell Surgery
Phtothermal nanoblade utilizes ultrahigh speed pulse laser induced cavitation bubble to rapidly cut live cell membrane with minimal perturbation. By controlling the light pulsing conditions such as polarization, pulse duration, and metallic nanostructures, cavitation bubbles can be shaped, synchronized to form patterned explosion in micro and nanometer scales. Our research in this direction focuses on studying the fundamental physics of such metallic nanostructure guided explotion, and developing devices based on these new understanding to enable novel nanofluidic devices for biomedical applications.
Selective Publication
-Frencha, C. T., Toescaa, I. J., Wu, T.-H., TeSlaac, T, Beatya, S. M., Wonga, W., Liua, M. H, Schrodera, I. S., Chiou, P. Y., Teitell, M. A., Miller, J. F.,ˇ¨ Dissection of the Burkholderia intracellular lifecycle using a photothermal nanoblade,ˇ¨ Proceedings of the National Academy of Sciences, Vol 108, pp 12095ˇV12100, 2011.
- Wu, T.-H., Teslaa, T., Kalim, S., French, C. T., Maghadam, S., Wall, R., Miller, J. F., Witte, O. N., Teitell, M., and Chiou, P. Y., ˇ§Photothermal nanoblade for large cargo delivery into live mammalian cells,ˇ¨ Analytical Chemistry, 83, pp 1321ˇV1327, 2011. (highlighted in Chemical & Engineering News: Cargo Delivery To Cells Gets Supersized)
-Wu, T.-H., Teslaa, T., Teitell, M., Chiou, P. Y., ˇ§Photothermal nanoblade for patterned membrane cutting," Optics Express, Vol. 18, pp. 23153-23160 , 2010.
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Laser Driven Ultrafast Microfluidics
Pulse laser induced breakdown is a novel microfluidic actuation mecahnism. By tightly focusing a short laser pulse in the water medium in a microfluidic channel, strong cavitation bubble can be generated by breaking down water molecules and created hot plasma. Such strong, transient, vapor cavitation bubble can generate large, localized mechanical forces and be utilized to pump, mix, and streer fluid in microfluidic channels at high speed. Our research in this direction focuses on developing novel high speed microfluidic devices to enable unique biomedical applications, such as a high speed microfluidic fluorescece activated cell sorter (microFACS), high speed droplet generator.
Selective Publication
-Park, S., Wu, T.-H., Chen, Y., Chiou, P. Y., ˇ§Pulse laser driven ultrafast droplet generation on demand,ˇ¨ Lab on a Chip, 11, pp. 1010 - 1012, 2011. (Selected as Lab Chip HOT article: Precise, high speed droplet formation )
-T.-H. Wu, L. Gao, Y. Chen, K. Wei, P. Y.Chiou, ˇ§Pulse Laser Trigger High Speed Microfluidic Switch,ˇ¨ Applied Physics Letter, Vol. 93, pp. 144102, 2008. (article selected for the October 20, 2008 issue of Virtual Journal of Nanoscale Science & Technology)
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