Our research has focused on metabolism, including its biochemistry, regulation, and re-design. We use metabolic engineering, synthetic biology, and systems biology principles and tools to construct microorganisms to assimilate carbon, metabolize carbon, and produce biofuels and chemicals more efficeintly. We also develop mathematical models for investigating metabolism and guiding engineering design.
Currently, our main projects include engineering proteins and biochemical pathways for CO2 fixation and produciton of fuels and chemicals. Our ultimate goal is to use biochemical methods to replace petroleum processing and to treat metabolic diseases.